Get Andrew Payne on Dwarkesh Podcast
Next goal: 10
The Case for This Conversation
Currently: CEO @E11BIO building technology for mapping entire mammalian brains. Previously: PhD @MIT with @eboyden3 & @insitubiology.
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Andrew Payne is the CEO of E11 Bio, a nonprofit building the tools to map entire mammalian brains, and in September 2025 he co led a preprint on combinatorial protein barcodes that enable self correcting neuron tracing, a concrete step toward scalable optical connectomics. That kind of technical breakthrough is exactly what the Dwarkesh Podcast is great at unpacking, from the science to the downstream impacts on AI and medicine.
E11 Bioβs public roadmap says they are releasing initial methods and data, then targeting roughly 10x growth in barcode diversity and image volume each year to reach a full mouse connectome within five years, and they are actively seeking partners right now. If Payne lays out where the bottlenecks are and what support is needed, it could shape how funders, labs, and policymakers prioritize brain scale mapping in 2026.
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Nomination created on December 5, 2025